Surgery News

VTT Technical Research Centre develops 3-minute MR image assessment method

April 10, 2016

The developed model structurally reaffirms the experimental observations which link ApoE4 to this pathology. Researchers have observed that this protein tends to lose its functional structure in presence of the peptide Amyloid beta; this however does not occur with the ApoE2 and ApoE3 forms. According to researchers, these differences are due to subtle divergences between the structures of each form and would explain the different responses of carriers of forms 3 and 4 in the presence of Amyloid beta molecules.

The loss of the structure reveals the possibility of new explorations aimed at better understanding and fighting against Alzheimer's disease. The following stage of the study will consist in experimentally characterising this interaction, which is an essential aspect in the design of future therapies. Researchers also highlight that this project has made even more obvious the need for computer tools in all fields of research and of the new possibilities they represent in improving the study of complex molecular systems.

Source: Universitat Autonoma de Barcelona