Surgery News

Twelve residents receive one-year fellowship grant to study medical dermatology

December 18, 2015

Serum IgA autoantibodies play significant roles in the pathogenesis and severity of several human inflammatory diseases including rheumatoid arthritis, SLE, lupus nephritis, and IgA nephropathy. For instance, in SLE patients of both Caucasian and African American ethnicities, the proinflammatory Gly248 allele in FcAR is enriched. "This invention assumes greater significance given that FcAR is the cognate receptor for IgA antibodies, and that Gly248 allele correlates to the severity of the disease. This FcAR polymorphism is essential to understand the early onset, severity patterns, and progression of IgA-mediated autoimmune diseases," said Ramakrishnan.

In autoimmune disease settings, both IgA and IgG autoantibodies (and their immune complexes) play independent roles in modulating the immune responses. IgGs modulate immune responses through FcGRs. "Therefore, rational patient stratification approaches that take into consideration of the polymorphisms in FcAR and FcGRs (3A, 2A, 3B, and 2B) can provide a transformative framework to better understand the disease severity patterns and variations in treatment response in patients. Our theragnostic products provide just that framework," explained Ramakrishnan.