Surgery News

New probe for identifying chemical process affected proteins functions like GPS

February 08, 2016

The HerbalScience study also used advanced DART (Direct Analysis in Real Time) Time-of-Flight mass spectrometry technology to generate detailed chemical profiles of each extract in order to determine the key bioactive compounds. Only 5% of the compounds were known chemicals, with the remaining 95% being identified for the first time. With further chemical analysis and identification of key bioactives, highly standardized extracts such as these could offer a rich new source for potential drug discovery for Alzheimer's and other therapeutic targets.

The journal article detailing the study will appear in the December 2009 issue of Current Alzheimer's Research (Vol. 6, No. 6). Authors are R. Douglas Shytle, Paula C. Bickford, Kavon Rezai-zadeh, L Hou, Jin Zeng, Jun Tan, and Paul Sanberg, with University of South Florida College of Medicine affiliations including the Department of Neurosurgery Center for Excellence in Aging and Brain Repair, Department of Psychiatry and Behavioral Medicine Silver Child Development Center, and Neuroscience Program; Cyndy D. Sanberg of Natura Therapeutics, Inc., Tampa, Florida; Bill Roschek Jr. and Randall S. Alberte, of HerbalScience Group LLC, Naples, Florida; and Ryan C. Fink, Department of Biochemistry and Molecular Biology, The University of Miami Leonard M. Miller School of Medicine, Miami, Florida. Dr. Bickford is also affiliated with the Veterans Administration Hospital, Research Service, Tampa, Florida; and Drs. Shytle, Bickford, Tan, and Paul Sanberg are also affiliated with Natura Therapeutics.

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